Insomnia and the Blues

A new study published in the journal Sleep reveals that people with insomnia are more likely to develop depression later in life. The traditional thinking is that insomnia is a symptom of depression, but the authors argue that insomnia may come before depression.

My take on this is: "So what,this is old news". However, if you were to look at insomnia from a sleep-breathing paradigm which I describe in my forthcoming book, Sleep, Interrupted the issue becomes a lot more complex and all that more meaningful.

In the book I propose that both insomnia and depression are manifestations of interrupted breathing while sleeping that deprives you of deep, restful, restorative sleep. This process begins in early childhood, and is affected by multiple factors, including anatomic issues, diet, infections or stressful situations.

The beauty of my sleep-breathing paradigm is that it doesn't contradict what's out there in insomnia knowledge and research. Instead, it suggests a revolutionary approach on thinking about medical concepts that we take for granted. For the most part, it even agrees with and supports the evidence in insomnia research. My theory is that it's not important which comes first (insomnia or depression), but that both can coexist together. If this is so, what can cause both to occur?

This is another example of the peculiarities of medical research when you try to isolate and correlate one variable against another. Yes, you'll get some interesting results, but more often than not, you'll end up asking more questions as a result, or end up with multiple conflicting results. Once you look at humans as a complex interaction of innumerable processes, by looking at the "big picture," things just make more sense. This is one of my overriding themes in my book.

The New York Deli Phenomenon

One of my biggest pet peeves is whenever I order a deli sandwich, the deli guy sometimes forgets one or more of my requested ingredients. For example, if I order a roast beef on a roll with lettuce, tomato, mayo, mustard, onions and sweet peppers, the last few ingredients are typically left out. Usually, it's the ingredients listed at the end, never the first few items. Ever since I noticed this, I watch the sandwich maker like a hawk. I hate it when they have to turn their backs to me to make a sandwich, since I can't see what they're doing. Every time I let my guard down, I always regret it.

You may be asking by now what this has to do with sleep and breathing and medicine in general. Unfortunately, too much.

When it comes to medical diagnoses, many physicians are guilty of the same phenomenon. For example, when I had to learn about obstructive sleep apnea in medical school, I had to memorize a long list of signs and symptoms. Usually, they're listed in order of importance. By the time you get to the 39th or 40th sign and symptom, your brain can't memorize any more. Most multiple test exams in medical school test you on the more common signs or symptoms, and rarely an unusual one. So by default, we tend to memorize the items higher on the list.

But this is where the problem starts. For example, going back to the obstructive sleep apnea example, the most frequent findings that are mentioned in textbooks or in a lecture are: older, obese, snoring, male, and big neck. Since these were the features first described in obstructive sleep apnea, no wonder. But if you read further down the list or look at published studies on this condition, you'll find dozens or even hundreds more common and uncommon features that no one has time to list out when asked about this condition. So lecture after lecture, I've seen the same description about obstructive sleep apnea: typically seen in older, snoring, obese men, and untreated, can lead to diabetes, high blood pressure, heart disease, heart attacks and strokes. It still continues to this day, even with numerous studies showing that obstructive sleep apnea can occur even in young thin women that don't snore. Of course, in a young thin woman complaining about sinus infections or fatigue, sleep-breathing problems are near the bottom of the list.

Despite the facts that doctors know about obstructive sleep apnea in the typical patients, they forget about the second part: the link with heart disease, heart attack and stroke. It's shocking to me how many people I see that have suffered from heart attacks or strokes that are found to have significant obstructive sleep apnea when eventually tested. The same can be said about sinusitis, throat infections, ear infections, etc. Too often, ear pain alone with no obvious infection is treated with antibiotics.

It's obvious that a human being is not a deli sandwich. To label a person with "sinusitis" is like saying, remember to add nasal congestion, yellow pus, fever, facial pain, poor sleep, ear fullness, or post-nasal drip. The problem is that this list gets whittled down to yellow pus and facial pain. Or that obstructive sleep apnea patients snore and are overweight, Yes, the majority of people with these symptoms will have the respective conditions, but you're missing out on many other patients that only have poor sleep or ear fullness for sinusitis and post-nasal drip for obstructive sleep apnea.

So if you have post-nasal drip, and are treated for allergies, no wonder the medication didn't work. Without getting a full and complete medical history and thorough physical exam, it's hard to get a complete picture of what's going on. In this age of managed care and rushed doctor's visits, it's no wonder that we end up treating the symptoms only and almost never the true cause of the illness, leading to missed diagnoses and incorrect treatment regimens.

Unfortunately, the New York Deli phenomenon will continue, with doctors making diagnoses and prescribing treatment based on incomplete pictures. Just as an incomplete sandwich just doesn't taste right, an incomplete history and examination can lead to an unsatisfying outcome.